© Aria Analytics, 2015

Advanced Liquid Analysis for Industry and Healthcare

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A World of Information in a Drop

A 5iTech Company
Applicable in:
Milk Wine Beer  Juices
Industry  Paints & Coatings  Pharmaceuticals  Consumer Products 
Healthcare  IV Solutions Dosage and Mix Control  Counterfeit Medications  Contaminated Pharmaceuticsals  Medical Screening 
Better Quality  ...  Lower Cost ...  Improved Safety

Almost any complex liquid sample can be characterized by 

Aria Analytics’ novel acoustic technology.  The same sensor is 

used to test chemicals, coatings, drugs, and many other 

products. Using a single sample and instrument, we capture 

the sample’s unique “fingerprint” as the liquid undergoes its 

predictable natural drying process. The results contain 

important data related to its composition, physical and 

chemical changes. Currently, similar data is available only by 

running multiple tests on multiple analytical instruments 

followed by skilled interpretation. The Aria holistic approach to

analysis lowers both capital and operating costs per test. 

Quality Control


Due to its ability to detect even minute differences from one sample to another, the Aria technology is ideally suited to Quality Control and Quality Assurance.   Currently, any number of single analytical methods are used to detect liquid phase components (both in-process or finished products), measure product purity, or the  presence of adulteration or contamination. Aria offers a one-step inexpensive test to detect adulteration or contamination, thus eliminating need for a  combination of measurements from slow and expensive instruments.   The Aria technology has been tested in Quality Assurance applications in a number of industriesExamples of Quality Control applications in Food & Beverages,  Inks, Healthcare, and Paints and Coatings, follow: 
Because of their extremely high sensitivity to Brand Reputation issues - Quality Control & Quality Assurance - Food & Beverage producers can see an enormous benefit  from using Aria technology.  QC and QA are difficult areas for Food & Beverage producers due to unique limitations with respect to controls on raw materials or in-  process operations: a large percentage of the raw materials or finished products are imported, some from third world countries.
Quality Control of IV Solutions in Hospital Pharmacies
Aria’s single-measurement technologies can easily distinguish off  standard formulations. The test time is equal to the time it takes for a 2 microliter drop of liquid to dry. The results of such a comparison are represented in digital format. The figures at the right show, for example, clear differences  between inks formulated in volatile vs. aqueous solutions
1 –  Cranberry Juice; 2 – “False” Orange Juice; 3 –  Natural Orange Juice.

Food and Beverage

Food & Beverage products Aria has successfully tested include: Drinking water and ice Milk and dairy products Alcoholic Beverages (e.g. wine, beer) Fruit Juices Condiments Flavors and fragrances

Dairy Products

Juice Authenticity

To Test the Aria Technology, Juice 2 was  formulated to have the same physical  appearance and RATIO as natural Orange Juice
Inks are a broad set of colloidal systems of fine pigment particles  dispersed in an aqueous or organic solvent.  In addition to the  pigment, modern ink formulations contain various amounts of  many other ingredients collectively known as “vehicles”. These  additional ingredients include pH modifiers, humectants to retard  premature drying, polymeric resins to impart binding and allied  properties, antifoaming agents, wetting agents (control surface  properties), biocides to inhibit the fungal and bacterial growth that lead to fouling, and thickeners or rheology modifiers to control ink application). Measurements of many chemical-physical parameters of the ink  are required to control ink content and quality.


The Agency for Healthcare Research and Quality (U.S. Department of Health and Human Services) has  reported that “Medical errors are responsible for injury in as many as 1 out of every 25 hospital patients; an  estimated 48,000-98,000 patients die from medical errors each year. Errors in healthcare have been estimated  to cost more than $5 million per year in a large teaching hospital, and preventable health-care related cost the economy $17-$29 billion per year.” These errors may result in a patient receiving the wrong medication, a test result being misread, or even a  misdiagnosis. A study by the Agency for Healthcare Research and Quality found that preventable adverse drug events caused 1 out of 5 injuries or death per year in the hospitals studied. A significant number of the  adverse drug events arise is the hospital pharmacy IV room. These errors are among some of the most difficult to detect and are extremely dangerous to the patient.
"IV doses are generally mixtures of clear liquids—once mixed, visual inspection of doses simply cannot uncover errors.  Human  diligence is simply insufficient.  In the course of their daily work, hospital pharmacists inspect hundreds, sometimes thousands, of IV preparations—the vast majority of which are correctly prepared. Finding the rare errors amongst hundreds of correct doses stresses human capability.”   Dennis Tribble, Chairman of the American Society of Health-Systems Pharmacists; Chief Technology Officer, ForHealth Technologies, Inc. 
Aria testing can be used both in-process and  for final IV formulations.   A simple, inexpensive test which requires  little technical expertise to perform provides  a simple straightforward indication of  whether or not the IV solution has been  prepared correctly and is ready for use.
The Aria technology uses a new trend in medical diagnostics - assessment of the morphology of human biological liquids in normal and disease states. This method provides highly informative rapid results by means of an easy to use, low-cost device.   To evaluate the potential of using this method in medical diagnostics, preliminary studies were performed in Russia with blood plasma and serum from women in different physiological and pathological states, and with blood serum from patients with paraproteinemia.  Additional studies were performed on serum from patients with viral hepatitis, patients who had suffered burns, and women with  breast cancer.   The figures below show data for healthy patients (data in White) vs patients suffering from various illnesses (data in Black). The clusters of white vs black data points provide a clear differential between healthy and unhealthy patients.   Aria is seeking partners to help develop these applications more fully.

Medical Screening

Industrial Applications

Aria’s platform technology offers numerous practical applications in a variety of industries. Through broad studies the  Aria team has shown its potential for many applications. In the table below are just few examples of Aria studies. 
In a similar way to its impact on Quality Assurance, the Aria technology is ideally suited to evaluating Product Performance at or near the point of sale.  The technology can easily measure: Shelf Life Dry Time Cure Time Accurate Mixing   Below are several examples of this type of application:

Polymer Solutions

Paints and Coatings

Aria Technology can easily evaluate samples of different paint batches for  variance from standard, both at the factory and at thepoint of sale.
The image at the right shows the results of comparing two different paints  against each other.  The curves for Paint 151 (in white) show a very stable  composition, while the curves for Paint 030 (in black) show changes in the  formulation as a function of shelf life.hese results are further emphasized in  the lower plot, which clearly shows the tight distribution of Paint 151  compared with the much wider distrbution in data for Paint 030 as a result of  aging.
Aria Technology can detect variance from standard in drinking water, both “from the tap, and bottled waters. The images at the right show dramatic differences in results from testing samples of mineral  water.
Different levels of mineralization, for example, lead to noticeably  different curve shapes for the various samles, allowing for easy  differentiation.


Contaminated & Counterfeit Products In the Chemicals, Food, and Pharmaceuticals areas, as well as in feedstocks for a number of other industries, contamination and  counterfeiting are major sources of financial loss. Contamination can occur at any stage of the supply chain, from raw materials sourcing through manufacturing, through shipping and  retail.  Of major concern is the rise of global raw material acquisition: companies dramatically increasing joint venture and strategic  partnerships outside the US, and US companies building manufacturing facilities outside the US.

Fraud & Tampering

Example: Counterfeit Drugs The current world pharmaceutical market is $541 billion dollars. According to the World Health Organization (WHO), counterfeit drugs  make up approximately 7% or $23 billion of the drugs sold into the US market.   The cost to the US healthcare system is huge due to complications, recalls, patient harm, law suits, increased testing, the need for  otherwise unnecessary patient care, and the cost to “fix the problem.”   To date, only one other method has been identified to test for counterfeit drugs: near IR scanning. Scientists conducting such testing in the US state that “…each device costs approximately $50,000 and is about the size of a suitcase, making widespread use unfeasible.”  Aria’s  method offers quick, reliable solution at a fraction of this cost
This figure shows the identification of the counterfeit drug in less than 15 minutes.   This drug is an injectable polypeptide manufactured in Austria for the treatment of  Alzheimer’s disease and ischemic stroke.  It has been approved for use in 44 countries and is in pre-clinical testing in the US.   This counterfeit has already entered the market.
The figure shows the raw data for a “good” lot of product (Green) with a counterfeit  lot (Red).    The Aria technology clearly distinguishes the difference.
Counterfeiting, on the other hand, is a purposeful attempt to defraud the buyer. Four basic categories of counterfeits are: Completely fraudulent counterfeit products with no active ingredients or benefit. Counterfeit products which contain poor-quality ingredients or a diluted active ingredient. Expired products that are re-packaged and resold. Products that mimic the proprietary formula using unknown raw materials/ingredients and manufacturing processes. Aria’s solution allows for rapid detection of deviation from standard formulations with contaminated and counterfeit products just as it  does its QC applications in manufacturing:
Aria provides a way to detect deviations from standard additives (or final  products) in a single measurement.  The figure to the right show an example of  various dilution levels for an aqueous solution of a proprietary polymer.  The red and green clusters represent two dilutions of the same polymer (“A”).  The blue  cluster represents a solution of a second polymer (“B”) at the same 1:2 dilution as  polymer “A” in green.  The clusters are clearly distinguishable from each other.
A major ingredient in many products starts as a solution of various polymers.  Polymer solutions are also commnon additives for non-polymer products. These  constituents are used in everything from paints, coatings, priniting, and packaging products to automotive, electronics, medical, and pharmaceutical applications.  Screening of incoming raw materials can catch problems with feedstock, but  testing usuallly requires a combination of measurements from slow and  expensive instruments.
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Varying Concentrations of Heparin

Countless Other

Applications ...